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Rock-wallabies are adapted to occupy specific rocky habitats, like outcrops, cliffs and caves Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Protecting rock-wallabies in Australia Last updated: 06/11/25, 11:54 Published: 29/05/25, 07:00 Rock-wallabies are adapted to occupy specific rocky habitats, like outcrops, cliffs and caves This is the final article (article no. 7) in a series on animal conservation. Previous article: Emperor penguins, kings of ice . First article: 55 years of vicuna conservation . Australia is home to many unique mammals because they have evolved in geographic isolation for millennia. Over 200 years ago, European colonists brought their own mammals to Australia, devastating this unique wildlife in ways that can still be seen today. One example is the rock-wallabies ( Petrogale spp. ), a group of 25 animal species and subspecies related to kangaroos. Australian scientists are monitoring rock-wallaby populations to ensure they remain safe from natural and human-caused threats. This article will describe those threats and how rock wallabies are being conserved. Rock-wallaby habitat As their name suggests, rock-wallabies are adapted to occupy specific rocky habitats, including outcrops, cliffs and caves. Since they are primarily nocturnal, these habitats provide shelter in the daytime. Rock-wallabies have modified foot pads to grip tricky surfaces and access places their predators cannot. Recent research found that for two rock-wallaby species, their abundance is associated with more complex and rocky habitats. Because their habitat type is so niche and they rarely migrate, one small disturbance could wipe out an entire rock-wallaby population. This is reflected by their protections under Australian law: five types of rock-wallaby are classified as ‘vulnerable’, six as ‘endangered’, and one as ‘critically endangered’. Thus, the complex habitat of rock-wallabies is both a blessing and a curse. Threats to rock-wallabies Rock-wallabies are vulnerable or endangered mainly because of invasive predators such as foxes, cats, and goats. After being introduced from Europe during colonisation, these predators have eaten many wallabies and scared the rest into foraging elsewhere. If predators live between two rock-wallaby populations, there will be less migration and interbreeding, reducing overall genetic health ( Figure 1 ). In addition, rock-wallabies will not forage if predators are in an area, so they have limited food sources under high pressure ( Figure 1 ). Combined with these indirect reasons, direct predation by invasive mammals is the biggest threat to rock-wallaby survival. Invasive predators are not the only threats to rock-wallaby populations. Wildfires kill the plants that wallabies rely on for food and shelter, such as rock figs. For example, one wildfire in the 2019/2020 season destroyed about 38% of brush-tailed rock-wallaby habitat. The already dwindling rock-wallaby populations may disappear if the climate crisis makes wildfires less predictable and more severe. Native herbivores like the euro and invasive herbivores like goats may also compete with rock-wallabies for food. There is evidence that euros out-compete rock-wallabies when food supplies are limited, but no evidence for goats yet. Thus, fires and competition combine with invasive predators to endanger rock-wallabies. Translocation and monitoring Monitoring existing rock-wallaby populations and creating new ones by translocation are reducing the threats of predation, fire, and competition. Brush-tailed rock-wallabies were translocated to Grampians National Park in 2008, but most animals died by 2013. Scientists thought manually handling wallabies might make them stressed and more vulnerable to predators. From 2014 onwards, non-invasive monitoring procedures like cameras and faecal DNA monitoring reduced predation and increased the survival rate of young rock-wallabies. Meanwhile, black-flanked rock-wallabies were being translocated from four different source populations to Kalbarri National Park, hoping they would interbreed and create a new genetically diverse population. The project was successful, as microsatellite genotyping found that the translocated population had more heterozygotes and more alleles per locus than the source populations ( Figure 2 ). This population is predicted to grow until at least 2028 because it is diverse enough to avoid the inbreeding mentioned earlier. The Grampians and Kalbarri translocations show the importance of careful monitoring and genetic considerations for conserving rock-wallabies. Conclusion After invasive mammalian predators have decimated rock-wallaby populations throughout Australia for over 200 years, wildfires and herbivore competition make survival even more difficult. Conservation efforts are made harder by the specific and limited habitats that rock-wallabies need. However, translocation efforts which consider genetic diversity and the stress of manual handling keep rock-wallaby populations afloat. Written by Simran Patel Related article: Wildlife corridors REFERENCES Campbell, I. & Woods, S. (2013) Wildlife of Australia . Princeton, UNITED STATES: Princeton University Press. Kleemann, S., Sandow, D., Stevens, M., Schultz, D.J., Taggart, D.A. & Croxford, A. (2022) Non-invasive monitoring and reintroduction biology of the brush-tailed rock-wallaby (Petrogale penicillata) in the Grampians National Park, Australia. Australian Journal of Zoology . 69 (2): 41–54. Available from: https://www.publish.csiro.au/zo/ZO21009 (Accessed 10th December 2024). Lavery, T.H., Eldridge, M., Legge, S., Pearson, D., Southwell, D., Woinarski, J.C.Z., Woolley, L.-A. & Lindenmayer, D. (2021) Threats to Australia’s rock-wallabies (Petrogale spp.) with key directions for effective monitoring. Biodiversity and Conservation . 30 (14): 4137–4161. Available from: https://doi.org/10.1007/s10531-021-02315-3 (Accessed 9th December 2024). Morris, S.D., Johnson, C.N. & Brook, B.W. (2020) Roughing it: terrain is crucial in identifying novel translocation sites for the vulnerable brush-tailed rock-wallaby (Petrogale pencillata). Royal Society Open Science . 7 (12): 201603. Available from: https://royalsocietypublishing.org/doi/full/10.1098/rsos.201603 (Accessed 10th December 2024). Nilsson, K., Pearson, D., Paxman, M., Desmond, A., Kennington, J., Byrne, M. & Ottewell, K. (2023) Translocations restore a population of a threatened rock-wallaby and bolster its genetic diversity. Conservation Genetics . 24 (5): 547–561. Available from: https://doi.org/10.1007/s10592-023-01520-7 (Accessed 9th December 2024). Silcock, J.L., Gynther, I.C., Horsup, A., Molyneux, J., Wattz, T.L., Fairfax, R.J., Healy, A.J., Murphy, D. & McRae, P.D. (2024) Half a century of survey data reveal population recovery but persistent threats for the Vulnerable yellow-footed rock-wallaby in Queensland, Australia. Oryx . 1–13. Available from: https://www.cambridge.org/core/journals/oryx/article/half-a-century-of-survey-data-reveal-population-recovery-but-persistent-threats-for-the-vulnerable-yellowfooted-rockwallaby-in-queensland-australia/D976E61ABE458B9FADA059372117382E (Accessed 10th December 2024). Project Gallery

A restored wildlife reserve in Mozambique Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link How Gorongosa National Park went from conflict to community Last updated: 06/11/25, 11:53 Published: 27/03/25, 08:00 A restored wildlife reserve in Mozambique This is article no. 5 in a series on animal conservation. Next article: Emperor penguins, the kings of the ice . Previous article: Pangolins: from poached to protected . Gorongosa National Park was the centre of a dark time in Mozambique’s history, which led to most mammals being hunted and entire species going locally extinct. Over the last 20 years, a public-private collaboration has restored many of these species and made Gorongosa National Park a healthy ecosystem again. In this article, I explore what nearly wiped out Gorongosa’s mammals and how they are doing today. About Gorongosa National Park Gorongosa National Park is a wildlife reserve in Mozambique containing grasslands, savannahs, woodlands, and wetlands. It lies at the East African Rift's southern end, making for a complex geological landscape centred around Lake Urema ( Figure 1 ). Lake Urema and the rivers draining into it support a high diversity of herbivorous mammals like elephants, zebras, and antelopes. Civil war and subsequent recovery Gorongosa National Park has illustrated the connections between society and ecology for decades. Civil war raged in Mozambique between 1977 and 1992. During this war, both sides hunted without restrictions in Gorongosa for meat and for valuable animal parts like ivory, which were exported to pay for ammunition. This decreased the population sizes of all animal species in the national park by at least 90%. Twelve years after the war ended, an American non-profit called the Gregory Carr Foundation partnered with the government of Mozambique to conserve and restore Gorongosa. The initiative, now called the Gorongosa Project, aims to bring back mammal species which went locally extinct in the war. In addition to providing healthcare, jobs, and education to 200,000 people living near the national park, the Gorongosa Project invests in tourism and ecological research. Ecologists are interested in how different animal species would rebound from the war and how a diverse ecosystem could be created nearly from scratch. By fostering healthy connections between local communities, scientists, and wildlife after the Mozambican Civil War, the Gorongosa Project has become something special. How different animal species recovered after the Mozambican Civil War Since mammalian herbivores were the cornerstone of pre-war Gorongosa National Park, their recovery has been prioritised. The populations of most herbivores have increased since the Civil War but at varying rates. Waterbucks, a species of antelope, have dominated Gorongosa in the years following the war ( Figure 2 ). This could be because more waterbuck survived the war in the first place and/or because they naturally reproduced faster than other mammals. Stalmans et al. found that waterbucks were found to be growing as fast as they biologically could, as though they had infinite resources and no diseases or predators. Meanwhile, the populations of larger herbivores like hippos, buffaloes, and elephants, which used to dominate Gorongosa, are recovering much slower than waterbucks ( Figure 2 ). With this change in the herbivore community came changes in vegetation. According to Daskin et al., the amount of land covered by trees in Gorongosa increased by 34% between 1977 and 2012 ( Figure 3 ). This was because there were fewer elephants or other ‘browsing’ herbivores to clear out woody vegetation. Thus, the Mozambican Civil War altered the community structure of herbivorous mammals and plants in Gorongosa National Park. After herbivores showed signs of recovery, scientists turned to restoring carnivorous mammals. Lions were the only carnivores not to go locally extinct during the war, so they recovered fastest. Between 2012 and 2016, Bouley et al. counted 104 lions in Gorongosa – about half the pre-war count. Following the success of lions, wild dogs were introduced from two different South African populations in 2018 and 2019. Over the following three breeding seasons, 82 pups were born, and dogs originally from different populations naturally formed their own packs. Wild dogs and lions prefer different prey and hunt in different habitats within Gorongosa, allowing both carnivores to coexist. This successful restoration of mammalian carnivores completed Gorongosa National Park’s post-war ecosystem. Conclusion After most mammals in Gorongosa National Park were hunted during a civil war, the Gorongosa Project restored a functioning ecosystem by diligently monitoring wildlife and working alongside local people. The park has brought attention to the often neglected non-human impacts of war. Conservationists are optimistic that if Gorongosa National Park’s ecosystem can recover from almost nothing, it is not too late to save other damaged ecosystems. Although Gorongosa’s ecosystem today is dominated by waterbucks, time will tell whether populations of carnivores and larger herbivores will return to their former glory. Written by Simran Patel Related articles: Galapagos tortoises / Vicuna conservation / Wildlife corridors REFERENCES Stalmans, M.E. et al. (2019) ‘War-induced collapse and asymmetric recovery of large-mammal populations in Gorongosa National Park, Mozambique’, PLOS ONE , 14(3), p. e0212864. Available at: https://doi.org/10.1371/journal.pone.0212864 . Daskin, J.H., Stalmans, M. and Pringle, R.M. (2016) ‘Ecological legacies of civil war: 35-year increase in savanna tree cover following wholesale large-mammal declines’, Journal of Ecology , 104(1), pp. 79–89. Available at: https://doi.org/10.1111/1365-2745.12483 . Bouley, P. et al. (2018) ‘Post-war recovery of the African lion in response to large-scale ecosystem restoration’, Biological Conservation , 227, pp. 233–242. Available at: https://doi.org/10.1016/j.biocon.2018.08.024 . Bouley, P. et al. (2021) ‘The successful reintroduction of African wild dogs (Lycaon pictus) to Gorongosa National Park, Mozambique’, PLOS ONE , 16(4), p. e0249860. Available at: https://doi.org/10.1371/journal.pone.0249860 . Gorongosa National Park (2020) Our Mission , Gorongosa National Park . Available at: https://gorongosa.org/our-mission-2/ (Accessed: 8 December 2024). Poole, J. et al. (2023) ‘A culture of aggression: the Gorongosa elephants’ enduring legacy of war’, Pachyderm , 64, pp. 37–62. Available at: https://doi.org/10.69649/pachyderm.v64i.518 . Project Gallery

Dive into the latest biological research! Explore the profound impact of negligent exercise on well-being, discover breakthroughs in organoid and iPSC research, and gain insights into how biomarkers are enabling disease diagnosis and prevention. Biology Articles Dive into the latest biological research! Explore the profound impact of negligent exercise on well-being, discover breakthroughs in organoid and iPSC research, and gain insights into how biomarkers are enabling disease diagnosis and prevention. You may also like: Cancer , Ecology , Genetics , Immunology , Neuroscience , Zoology , and Medicine Can a human brain be uploaded to a computer? Uncovering the possibilities of transferring information from your brain to a computer Impacts of negligent exercise on physiology How to avoid negligent personal training as it can harm the individual Key historical events in public health A timeline of discoveries in the history of public health Influence of different environmental factors on exercise How different environmental factors can affect exercise Why bacteria are essential to human survival The benefits of bacteria Will diabetes mellitus become an epidemic? Diabetes mellitus is when the body is unable to produce enough insulin or becomes resistant to it Correlation between a country's HDI and COVID-19 mortality rate HDI stands for Human Development Index, i.e. how much a country is developed considering various factors such as wealth Rising food prices Food deserts and malnutrition Organoids in drug discovery What organoids are, their applications in drug discovery and more The genesis of life What came first: the chicken or the egg? Challenges in endometriosis Form underreporting to under-research iPSCs and organoids iPSC stands for induced pluripotent stem cells PCOS and endometriosis These two diseases are very similar, but how are they different? Neutrophil gelatinase-associated lipocalin (NGAL) A biomarker for renal damage Childhood stunting Its issue in developing countries Innovations in the biosciences The biggest ones currently Various health models Understanding health through different stances Medicinal Manuka The benefits of using Manuka honey as medicine The dual role of mitochondria A mechanism for survival, or death? Next

Sharpen your knowledge on this subject with articles dissecting the branch of behavioural economics (the role of honesty, endowment effect, loss of aversion, libertarian paternalism, effect of time), among others. Economics Articles Sharpen your knowledge on this subject with articles dissecting the branch of behavioural economics (the role of honesty, endowment effect, loss of aversion, libertarian paternalism, effect of time), among others. You may also like: Maths The role of honesty Article #1 in a series on behavioural economics The endowment effect Article #2 in a series on behavioural economics Loss aversion Article #3 in a series on behavioural economics Libertarian paternalism and the 'Nudge' approach Article #4 in a series on behavioural economics

The secrets of the brain are secrets no longer; the field of neuroscience is rapidly expanding day by day. Read articles which discuss Parkinsonism, Huntington’s, degeneration, Alzheimer’s, and more. Neuroscience Articles The secrets of the brain are secrets no longer; the field of neuroscience is rapidly expanding day by day. Read articles which discuss Parkinsonism, Huntington’s, degeneration, Alzheimer’s, and more. You may also like: Biology , Immunology , Medicine Synaptic plasticity and London taxi drivers Synaptic plasticity and navigating our surroundings Stress and neurodegeneration And how the hormone cortisol plays a significant role Markers for Parkinsonism Exploring the role of TDP43 The wonders of the human brain A basic overview of brain function The brain-climate connection Can rising temperatures really affect our brains? Schizophrenia and accelerated ageing A complex medical phenotype Squid axons And how they were fundamental to discoveries in neuroscience Alzheimer's disease Its pathology and potential treatment Serial killers Their neurological basis Huntington's disease A rare, inherited, debilitating neurological disease Electricity in the body Luigi Galvani 's work PTSD and intrusive memories Article #1 in a series on Post Traumatic Stress Disorder and traumatic memories Mobility disorders Hypermobility spectrum disorders vs. Hypermobile Ehlers-Danlos Syndrome Brief neuroanatomy of autism Autism is a neurological and developmental disorder Oliver Sacks Who was this famous neuroscientist? A treatment for Huntington's disease Antisense oligonucleotide gene therapy PTSD and Tetris Article #2 in a series on Post Traumatic Stress Disorder and traumatic memories The dopamine connection The link between the brain and the digestive system Neuromyelitis optica (NMO)- Devic disease How is it different to Multiple Sclerosis? Article #8 in a series on Rare diseases. DFNB9 How was this form of deafness treated for the first time? Next

Resources to help you prepare for university admission. Entrance Exam Preparation Resources to help you with university admission for: medicine , dentistry, natural sciences , physics , maths , engineering . Do note these entrance exams are mainly for UK universities, but can be used for international unis too. It is advised to check with the university when applying. You may also like: Personal statements , A-level resources, IB resources and Extra resources MEDICINE: University Clinical Aptitude Test (UCAT) UCAT resources: UCAT website / The Medic Portal / 6med UCAT Books: 1300 UCAT Practice Questions / 1250 UKCAT Practice Questions / UCAT 700+ UCAT online course: Medify Help with medical exams DENTISTRY: UCAT and BioMedical Admissions Test (BMAT; for University of Leeds only) Dentistry application preparation BMAT: online mastery course / Medify guide / Past papers / 700 BMAT Practice Questions / BMAT ebook For UCAT resources, see above OTHER ADMISSION TESTS Engineering: STEP / PAT University of Cambridge: natural sciences (NSAA) / engineering (ENGAA) / maths (STEP) / physics (PAT)

Have you perform the wrong exercises – You must keep revising your exercises and keep upgrading your knowledge about the proper use of equipment, and everything else related to fitness so that you don’t make any mistake in giving your clients the wrong exercises Go back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Examples of negligence in personal training on the impact of physiology Last updated: 14/11/24 Published: 26/01/23 Negligence in personal training is a failure to look after clients to avoid them getting injured while training. There are many ways this can happen, below are some examples of negligence in personal training. Making use of equipment that is defective – Using a defective equipment can easily lead to injury or at least poor exercising form. Trainers should be able to differentiate between effective and defective equipment if they want to avoid negligence in training their clients. In that scenario, the best thing a personal trainer can do is to repair the equipment or replace it with new ones instead of putting a ‘defect’ or ‘out of order’ sign on it. Telling you to lift too much weight – You can’t just tell your clients to lift too much weight without even knowing their capacity, their way of eating and experience from past training. This is irrational and unprofessional, thus neglecting your clients directly which can lead to causing them injuries like muscle tears, muscle strains and even worse, a wrong death. Have you perform the wrong exercises – You must keep revising your exercises and keep upgrading your knowledge about the proper use of equipment, and everything else related to fitness so that you don’t make any mistake in giving your clients the wrong exercises to do that can lead to stopping them from achieving their desired physiques, and fitness goals. Muscle imbalances will occur as well if not done properly. Make you exercise for too long – Exercising for too long can cause excess fatigue and can lead to muscle strains and sprains. Coaches must not let their clients push themselves too far. It may sound cool but it is not really healthy. Everything we do must be done in an appropriate manner to avoid consequences that will harm us. Written by Kushwant Nathoo Related articles: A perspective on well-being / Gentrification in the context of health

Conservation, diseases, animal behaviour, adaptation and survival. Expand your knowledge on the incredible diversity of life on Earth with these articles. Zoology Articles Conservation, diseases, animal behaviour, adaptation and survival. Expand your knowledge on the incredible diversity of life on Earth with these articles. You may also like: Biology , and Ecology Deception by African birds The species Dicrurus adsimilis uses deception by flexible alarm mimicry to target and carry out food-theft attempts An experiment on ochre stars Investigating the relative fitness of the species Pisaster ocharceus Orcinus orca A species report Rare zoonotic diseases We all know about COVID-19. But what about the other zoonotic diseases? Article #1 in a series on Rare diseases. Marine iguanas Their conservation The cost of coats 55 years of vicuna conservation in South America. Article #1 in a series on animal conservation around the world. Conserving the California condor These birds live on the west coast of North America. Article #2 in a series on animal conservation around the world. Emperor penguins Kings of ice. Article #6 in a series on animal conservation around the world. Protecting rock-wallabies in Australia A group of 25 animal species, and subspecies related to kangaroos. Article #7 in a series on animal conservation around the world. Do other animals get periods? Looking at menstruation in non-human animals e.g. monkeys, bats Same-sex attraction in non-human animals SSSB in birds, mammals, and invertebrates Changing sex in fish Why some fish change sex during their lifetimes

An individual may be restricted to a certain range of physical activities which they can participate in. Individuals are usually reliant on the surrounding environment and the maintenance of facilities. If they are not kept well maintained, individuals are usually discouraged. Go back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Influence of different environmental factors on exercise Last updated: 30/01/25 Published: 10/02/23 The characteristics of environmental factors: - Chemical safety - Air pollution - Climate change and natural disasters - Diseases caused by microbes - Lack of access to health care - Infrastructure issues - Poor water quality - Global environmental issues What are the impacts of these environmental influences on physical activity? An individual may be restricted to a certain range of physical activities which they can participate in. Individuals are usually reliant on the surrounding environment and the maintenance of facilities. If they are not kept well maintained, individuals are usually discouraged. The physiological effect on training: Climate change will disproportionately affect the most vulnerable in our populations, including the very young, the very old, and those with pre-existing health conditions. Training adjustments to compensate for the influence of environmental factors on training: - Treatments for heat stress- stop exercising / move to a shaded or air-conditioned area / remove excess clothing or equipment / drink cold beverages / sit in front of a fan / put a cool piece of cloth around neck / place entire body in cool water e.g. cool bath or shower - Treatments for cold stress- move to a warm environment / remove cold and wet clothes / find access to warm air such as heaters, or fireplace / use electric or non-electric blankets / drink warm beverages Written by Kushwant Nathoo Related articles: Impacts of negligent exercise on physiology / Physical and mental health / Environmental impact of EVs

When deciding on the treatment of diseases, experts must gain as much relevant information as they can about that disease, before acting on an informed decision. When cancer is suspected, it might be that the decision for future treatment and prognosis be heavily weighted on the results of biopsies Go back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Cancer biomarker and evolution Last updated: 27/02/25 Published: 30/01/23 Development of Novel Biomarkers by Studying Cancer Evolution What does cancer evolution mean to cancer diagnosis and prognosis? How does studying it provide a better outlook on cancer precision medicine? =================== When deciding on the treatment of diseases, experts must gain as much relevant information as they can about that disease, before acting on an informed decision. When cancer is suspected, it might be that the decision for future treatment and prognosis be heavily weighted on the results of biopsies. After all, this is the standard for diagnosing many cancers. It takes one needle to take “information” that is used to predict patients’ outcomes and their respective treatment options, in other words, a test that might just predict their future. Cancer is an evolving disease. There have been many studies over the decades that demonstrate solid cancers’ singular-cell origins. Other studies show how cancer may evolve from a single cell to a mass of cells through Darwinian or branched evolution. This also implies that many things that apply to other evolutionary phenomena also apply to evolving cancer lines: mutation, genetic drift, selection and their selection pressures. In the end, what originated from one cell turns out to be a tumour with a unique genetic landscape, made up of numerous cancer subpopulations, each with its own unique genotypic and phenotypic profile and each of these subpopulations of cancerous cells evolving on its own. This phenomenon is more commonly referred to as intratumor heterogeneity (ITH). What all of this means to biopsies, is that when a single-site needle biopsy is done, it might not give an accurate representation of the whole tumour. The tumour itself, depending on its stage of development may be quite uniform with minimal ITH, however, it may also, in the eyes of a geneticist, look like a mosaic with multiple different “populations” of cancerous cells. Say, for example, the biopsy is aimed to target certain biomarkers (e.g. single nucleotide polymorphisms (SNPs)) or other “landmarks” such as satellites, the biopsy will only view whatever the needle so happened to have sampled. In other words, sampling could have made it look like a mosaic is red, even though the majority of the mosaic at the time is blue, but it seemed red for we only found red during the biopsy. Additionally, this mosaic is changing, new colours may emerge just like new lines arise within the same tumour. ITH introduces what is known as sampling bias, where samples taken from biopsies only provide an overview or snapshot of the tumour at its state and only pick up on one piece of the actively evolving puzzle, potentially missing many details, in this case, biomarkers from other tumour subpopulations. To solve the issues of ITH, scientists participating in the TRACERx research consortium are employing unique methods to sample tumours in an approach to cancer evolution. The research involved using multiregional sampling and RNA sequencing to sample tumours from patients with non-small cell lung cancers (NSCLC) at different timestamps, i.e. during the various stages of cancer development, metastasis and relapse. By using this approach, the team managed to document better how cancer evolves and how the genomic landscape and tumour architecture changes over time. Furthermore, they succeeded in honing genes that are uniformly conserved and expressed throughout the tumour, even after the effects of ITH. The research looked over 20,000 expressed genes and found 1,080 genes that despite cancer evolution and ITH, are relatively conserved and clonally expressed, relatively unaffected by sampling bias. Furthermore, using machine learning, 23 genes (from the 1,080) were found to be predictive of patient outcomes. Meaning, this novel set of genes or “biomarkers” may be used as a basis for prognosis and to predict mortality in NSCLC. This novel biomarker is named ORACLE or Outcome Risk Associated Clonal Lung Expression signature and scientists are hopeful that it may be used to determine the relative aggressiveness of lung cancers, whilst maintaining a robust function unaffected by ITH. By targeting ORACLE, it mattered less where the biopsy needle is placed on the tumour, as these genes are found clonally. In terms of its effectiveness, a trial shows that having high scores of ORACLE signatures is associated with an increased risk of death within five years of diagnosis. In addition, other trials show that by targeting ORACLE, scientists were able to identify patients with a substantial risk of poor clinical outcomes. Overall, research on the application of ORACLE has shown satisfactory results in predicting patient outcomes and is found to be relatively resistant to the confounding effects of ITH. In summary, we have seen what cancer evolution may cause, and how it shadows the effectiveness of conventional biopsies and biomarkers due to sampling bias in ITH. We also find the research by the TRACERx Consortium and how they aim to study the effects of cancer evolution and ITH, finding a set of genes that are found and expressed throughout the tumour, yet still provide a favourable measure to patient outcomes. Whilst these topics are still under active research, it is clear, how studying cancer evolution and changing the approach to biopsies and biomarker designs can improve the overall quality of diagnosis and cancer prognosis. After all, finding what is wrong is as important as fixing the problem. We hope that similar biomarkers may be developed in the future, applicable to many other types of cancers. Written by Stephanus Steven Related articles: Thyroid cancer / Arginine and tumour growth / NGAL- a marker for kidney damage REFERENCES Biswas, D. et al. (2019) “A clonal expression biomarker associates with lung cancer mortality,” Nature Medicine, 25(10), pp. 1540–1548. Available at: https://doi.org/10.1038/s41591-019-0595-z. Header image: Lung cancer cells. Anne Weston, Francis Crick Institute. Attribution-Non-Commercial 4.0 International (CC BY-NC 4.0)